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Core Platform Module

Risk Management & ISO 14971 FMEA Engine

Proactive Risk Scoring with Severity Dominance and Statistical Drift Detection

Unlike static spreadsheet risk logs that gather dust until an audit, QMSdesk features an active Central Risk Intelligence Engine that connects risks directly to SOPs, deviations, change controls, and supplier performance scorecards.

ISO 14971:2019FDA QMSR (21 CFR 820)ISO 13485:2016 §7.1ICH Q9 (R1)GAMP 5 Risk-Based Testing

Key Capabilities & Functional Architecture

01

Dynamic FMEA Risk Matrix

Calculates Risk Priority Numbers (RPN) across Severity, Probability, and Detectability with qualitative hazard flows.

02

Severity Dominance Rule

Severity level 5 hazards immediately escalate to Critical status regardless of low probability to mandate oversight.

03

Proactive Drift Detection

Identifies quality anomalies where low-risk processes or suppliers show deviation spikes over a 30-day window.

04

ALARP Formal Acceptance

Unmitigable risks can be formally accepted with documented executive e-signatures and annual re-evaluation.

Built-In GxP Safeguards

Critical risk breaches automatically spawn linked CAPA records.

Pre-configured industry templates for Pharma, MedTech, Biotech, and CROs.

Residual risk recalculation after mitigation controls are verified.

Interactive Risk Engine Simulator

Dynamic ISO 14971:2019 / ICH Q9(R1) Risk Intelligence Core

See how QMSdesk automatically detects risk drift and auto-triggers CAPA workflows upon critical threshold breach.

Real-time Logic Active
Severity (Harm Impact)Level 4/5 (Major)
1 - Negligible2 - Minor3 - Moderate4 - Critical5 - Catastrophic
Occurrence LikelihoodLevel 3/5
1 - Improbable2 - Remote3 - Occasional4 - Probable5 - Frequent
Detection DifficultyLevel 2/5
1 - Almost Certain Detection3 - Moderate Detection5 - Undetectable

5x5 Risk Heatmap Coordinate

S5P1
S5P2
S5P3
S5P4
S5P5
S4P1
S4P2
S4P3
S4P4
S4P5
S3P1
S3P2
S3P3
S3P4
S3P5
S2P1
S2P2
S2P3
S2P4
S2P5
S1P1
S1P2
S1P3
S1P4
S1P5
Assessed Risk Status
HIGHRPN: 24
Raw Matrix4 × 3 = 12
Architectural Guardrails Applied:
  • ISO 14971 Hazard classification mapped automatically.
  • Cross-module traceability to SOPs, Audits, and Supplier records.
Automated Engine Response

⚠️ HIGH RISK: Flags 30-Day Cluster Alert and requires Quality Manager formal mitigation plan approval.

See Risk Management & ISO 14971 FMEA Engine in Action

Experience our 15-minute onboarding curve and turnkey GxP workflows with a live 1-on-1 walkthrough.